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Larry Ruvo on Family, Philanthropy, and the Fight Against Alzheimer’s | IAP 424

July 5, 2026 By Nicky Calvello-Macchia Leave a Comment

The Italian American Podcast welcomes Larry Ruvo for a heartfelt conversation with hosts Marcella Martin and Pat. The episode begins by exploring Ruvo’s family story, tracing the journey of his Italian Canadian and Italian American parents from Niagara Falls to Las Vegas, where they opened the Venetian Pizzeria, the city’s first pizzeria. Along the way, Ruvo shares colorful memories of family life, Frank Sinatra’s enduring loyalty to the restaurant, and an era when trust and a handshake were often the foundation of business.

 

The discussion then turns to Ruvo’s extraordinary philanthropic work and the founding of the Lou Ruvo Center for Brain Health in partnership with the Cleveland Clinic. Inspired by his father’s battle with Alzheimer’s disease and his mother’s dedication as a caregiver, Ruvo explains the center’s mission to advance research, improve patient care, and support families living with neurodegenerative diseases. He also highlights the center’s iconic Frank Gehry-designed building, the impact of the Women’s Alzheimer’s Movement, and the growing importance of gender-specific research, early detection, caregiver support, and private philanthropy in the search for better treatments and, ultimately, a cure.

 

Throughout the conversation, Ruvo, Marcella, and Pat reflect on the enduring values of family, education, faith, and community, while considering the challenges of preserving Italian American identity across generations. Filled with humor, personal stories, and thoughtful insights, the episode is a moving reminder of how heritage, compassion, and generosity can leave a lasting impact on both individuals and society.

HOSTS:
Patrick O’Boyle
Marcella Martin

SPECIAL GUEST:
Larry Ruvo

PRODUCED BY:
Nicholas Calvello-Macchia

Filed Under: Podcast

Previous Post: « Joe DiMaggio’s 56-Game Hitting Streak: Baseball’s Unbreakable Record? | IAP 423

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